GtxA is a virulence factor that promotes a Th2-like response during Gallibacterium anatis infection in laying hens
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چکیده
منابع مشابه
GtxA from Gallibacterium anatis, a cytolytic RTX-toxin with a novel domain organisation
Gallibacterium anatis is a pathogen in chickens and other avian species where it is a significant cause of salpingitis and peritonitis. We found that bacterial cells and cell-free, filter-sterilised culture supernatant from the haemolytic G. anatis biovar haemolytica were highly cytotoxic towards avian-derived macrophage-like cells (HD11). We obtained the genome sequence of G. anatis 12656-12 a...
متن کاملRecombinant proteins from Gallibacterium anatis induces partial protection against heterologous challenge in egg-laying hens
Gallibacterium anatis is a Gram-negative bacterium and major cause of salpingitis and peritonitis in egg-laying hens, thereby contributing to decreased egg production and increased mortality among the hens. Due to widespread drug resistance and antigenic diversity, novel prophylactic measures are urgently required. The aim of the present study was to evaluate the cross-protective capacity of th...
متن کاملGallibacterium anatis bacteremia in a human.
We describe the first case of bacteremia due to Gallibacterium anatis. The patient, a 26-year-old woman, developed bacteremia and diarrhea. The origin of infection was possibly due to a diet contaminated by G. anatis in this highly immunocompromised patient.
متن کاملNatural transformation of Gallibacterium anatis.
Gallibacterium anatis is a pathogen of poultry. Very little is known about its genetics and pathogenesis. To enable the study of gene function in G. anatis, we have established methods for transformation and targeted mutagenesis. The genus Gallibacterium belongs to the Pasteurellaceae, a group with several naturally transformable members, including Haemophilus influenzae. Bioinformatics analysi...
متن کاملComplete genome sequence of Gallibacterium anatis strain UMN179, isolated from a laying hen with peritonitis.
Gallibacterium anatis is a member of the normal flora of avian hosts and an important causative agent of peritonitis and salpingitis in laying hens. Here we report the availability of the first completed G. anatis genome sequence of strain UMN179, isolated from an Iowa laying hen with peritonitis.
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2020
ISSN: 1297-9716
DOI: 10.1186/s13567-020-00764-2